1-(3-Methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanones and ethanols: analgesic and antiinflammatory activities


PALASKA E., Ünlü S., Erdoǵan H., Safak C., Gümüsel B., Sunal R.

European Journal of Medicinal Chemistry, vol.28, no.12, pp.963-967, 1993 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 12
  • Publication Date: 1993
  • Doi Number: 10.1016/0223-5234(93)90052-g
  • Journal Name: European Journal of Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.963-967
  • Keywords: 2-BENZOXAZOLINONES, SYNTHESIS, ANALGESIC, ANTIINFLAMMATORY, CARRAGEENAN PAW EDEMA, DERIVATIVES
  • Lokman Hekim University Affiliated: No

Abstract

Eight new 1-(3-methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanone and 1-(methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanol derivatives were synthesized and their chemical structures elucidated by UV, IR, 1H-NMR and elemental analysis. The analgesic activity of these compounds was investigated by a modified Koster test and constant temperature hot-plate test. Antiinflammatory activity of the compounds was screened by using the carrageenan hind-paw edema test. All the compounds showed higher analgesic activity than aspirin. Carrageenan edema inhibition of the compounds was higher than indomethacin. None of the compounds induced gastric ulceration. © 1993.