Akademik Veri Yönetim Sistemi
PHARMACEUTICS, cilt.17, ss.1-25, 2025 (SCI-Expanded)
Abstract: Background: Acne is a prevalent dermatological condition characterized by the
blockage of hair follicles and sebaceous glands, leading to the formation of acne. The
anaerobe pathogen Cutibacterium acnes (formerly known as Propionibacterium acnes) plays
an essential role in the pathogenesis of acne, for which generally antimicrobial treatment
is required. Acne is a substantial health concern, and continuing research is being
conducted to discover novel and efficacious remedies. The antimicrobial activity of plants
has been demonstrated in numerous studies, and they are still targeted organisms in drug
development. Studies showing that plants are effective against acne pathogens have also
been reported. Methods: The antimicrobial activity of the hydroethanolic extracts
prepared from 30 plant species was determined against C. acnes standard strains (C. acnes
Scholz and Kilian ATCC 11827 and ATCC 11828) and 30 clinical isolates in our
preliminary screening. Since acne is an inflammatory skin disease, the anti-inflammatory
effect of six active extracts against C. acnes was determined through the in vitro inhibition
of collagenase, lipoxygenase (LOX), hyaluronidase and xanthine oxidase (XO) enzymes.
Results: Cotinus coggygria Scop. leaf extract displayed the highest hyaluronidase and
collagenase inhibition (79.75% and 52.52%, respectively), while the extract from the aerial
parts of Helichrysum arenarium (L.) Moench demonstrated a potent XO inhibitory effect
(82.51%). Therefore, these two extracts have been chosen for further studies, and LC/MS-
MS was used to determine the phenolic profiles of these extracts. Conclusions:
Subsequently, nanoemulgels were formulated with the active extracts to develop a
prototype herbal anti-acne product, and characterization studies of the formulations were
conducted.