The prevalence of homozygous mthfr polymorphism(S) in a turkish university hospital population that necessitated mthfr polymorphism investigation
Electronic Journal of General Medicine, cilt.15, sa.4, 2018 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.29333/ejgm/89674
- Dergi Adı: Electronic Journal of General Medicine
- Derginin Tarandığı İndeksler: Scopus
- Anahtar Kelimeler: Demographic analysis, Gene frequency, Genetic polymorphism, Methylenetetrahydrofolate reductase, Turkey
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Background: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms may cause various medical disorders through different mechanisms. We aimed to determine the allelic frequency and the prevalence of homozygous MTHFR polymorphisms in a tertiary university hospital population that necessitated MTHFR polymorphism investigation owing to various reasons. Methods: Our study consisted of 10449 patients who necessitated MTHFR polymorphism investigation owing to various reasons (coronary artery diseases, thrombotic events, epilepsy, migraine, repeated miscarriages, various obstetric complications) during 2008-2017. Results: The allelic frequency of MTHFR 677 and MTHFR 1298 mutations were 0.296 and 0.283 respectively. The prevalence of homozygous MTHFR C677T and MTHFR A1298C polymorphisms were 10.2 % and 11.1 %, respectively. Conclusion: MTHFR polymorphisms are more frequent than was expected and one should be cautious when drawing disorder specific conclusions.