Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines

Alkhatib R., Hennebelle T., Joha S., Idziorek T., Preudhomme C., Quesnel B., ...More

Phytochemistry, vol.69, no.17, pp.2979-2983, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 17
  • Publication Date: 2008
  • Doi Number: 10.1016/j.phytochem.2008.09.019
  • Journal Name: Phytochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2979-2983
  • Keywords: Ferula elaeochytris, Apiaceae, Sesquiterpene, Leukemia, Dasatinib, Imatinib, OLEANANE SAPONINS, ACID-DERIVATIVES, SESQUITERPENES, ROOTS, RESISTANCE, FERUTININ, COMMUNIS, ESTERS, RAT
  • Lokman Hekim University Affiliated: No

Abstract

Phytochemical investigation of the roots of Ferula elaeochytris made it possible to isolate two sesquiterpene esters, 6-anthraniloyljaeschkeanadiol (elaeochytrin A) and 4β-hydroxy-6α-(p-hydroxybenzoyloxy)dauc-9-ene (elaeochytrin B), as well as eight known compounds: 6-angeloyljaeschkeanadiol, teferidin, ferutinin, 6-(p-hydroxybenzoyl)epoxyjaeschkeanadiol, 6-(p-hydroxybenzoyl)lancerotriol, 5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid and sandrosaponin IX. The cytotoxic activities of all compounds were investigated on K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2BCR-ABL (dasatinib-resistant) mouse leukemia cell line. Elaeochytrin A was the most active compound on both cell lines (IC50 = 12.4 and 7.8 μM, respectively). It was also tested on non-resistant human promyelocytic leukemia cells (HL60, IC50 = 13.1 μM) and was not toxic to normal peripheral blood mononuclear cells up to 100 μM. © 2008 Elsevier Ltd. All rights reserved.