Spectrophotometric determination of active ingredients in tablets containing meclizine hydrochloride


ONUR F., DİNÇ E.

Scientia Pharmaceutica, vol.63, no.2, pp.113-126, 1995 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 1995
  • Journal Name: Scientia Pharmaceutica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.113-126
  • Keywords: meclizine hydrochloride, nicotinic acid, pharmaceutical analysis, pyridoxine hydrochloride, spectrophotometry
  • Lokman Hekim University Affiliated: Yes

Abstract

A new accurate and selective method for the determination of meclizine.HCl is developed. The method is based on the precipitation of yellow colored meclizine 3H 3[Fe(CN) 6] by the reaction of meclizine.HCl with potassium ferricyanide at pH 2. The solution of this precipitate in methanol shows maximum absorption at 420,8 nm. Relative standard deviation of the method was found to be 1,85%. This method has a selectivity for meclizine.HCl in the presence of pyridoxine.HCl and nicotinic acid. The method was applied to tablets containing meclizine.HCl alone and its binary combinations with pyridoxine.HCl and nicotinic acid. The quantification of pyridoxine.HCl and nicotinic acid in their mixture with meclizine.HCl was realized by reading dA/dλ values at 271,6 nm for pyridoxine.HCl and at 271,8 nm for nicotinic acid in the first derivative spectra of the remaining solutions after precipitation of meclizine.HCl with potassium ferricyanide. Relative standard deviation of the method was found to be 0.58% and 1.20% for pyridoxine.HCl and nicotinic acid respectively.