The Relationship Between Metabolic Syndrome Development and Tissue Trace Elements Status and Inflammatory Markers

Akdas S., TURAN B., DURAK A., ARIBAL AYRAL P., YAZIHAN N.

Biological Trace Element Research, vol.198, no.1, pp.16-24, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 198 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1007/s12011-020-02046-6
  • Journal Name: Biological Trace Element Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Page Numbers: pp.16-24
  • Keywords: Copper, Inflammation, Insulin resistance, Metabolic syndrome, Trace elements, Zinc, METAL LEVELS, ZINC LEVELS, LIVER, COPPER, MANGANESE, MODEL, IRON
  • Lokman Hekim University Affiliated: Yes

Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature.Insulin resistance, impaired glucose regulation, dyslipidemia, low-grade inflammation, and elevated blood pressure are main components of the metabolic syndrome (MetS). Trace elements, especially zinc (Zn) and copper (Cu) and cytokines, have physiological importance due to their presence in inflammatory processes and glucose metabolism. Therefore, this study aimed to investigate the potential relationship between cytokine responses and trace elements in different tissues of sucrose-induced MetS rats compared with healthy controls (n:7/groups). Tissue Zn concentrations are found to be decreased in the liver (p = 0.00) and pancreas (p ' 0.01) and increased in the kidney (p = 0.00) and heart tissues (p ' 0.001) of MetS group. Serum Zn levels were also found to be decreased in MetS compared with control group (p ' 0.01), while there was any significant difference in serum Cu concentrations between groups. The Cu concentration (p ' 0.01) was found decreased, and Zn/Cu ratio (p ' 0.01) was found increased in kidney tissues. TNF-α, IL-6 levels were found increased in MetS tissues. With this study, the Zn and Cu concentrations and their relationships with inflammatory response in different tissues in MetS are reported for the first time in the literature. Serum and tissue Zn levels with diversities in distribution were found to have a higher impact on MetS pathogenesis than Cu levels. It has been concluded that there is a relationship between Zn and Cu concentrations and inflammatory marker levels in MetS pathophysiological mechanisms.