Effect of docosahexaenoic acid on macrophage functions of rats


BÜLBÜL M., Tan R. , Gemici B., Hacioglu G., Agar A., Nimet Izgut-Uysal V.

Immunobiology, vol.212, no.7, pp.583-587, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 212 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1016/j.imbio.2007.04.004
  • Title of Journal : Immunobiology
  • Page Numbers: pp.583-587
  • Keywords: docosahexaenoic acid, macrophage, phagocytosis, chemotaxis, PURIFIED EICOSAPENTAENOIC ACID, FATTY-ACIDS, PERITONEAL-MACROPHAGES, DIETARY ENRICHMENT, INFLAMMATION, SUPPRESSION, MODULATION, PHAGOCYTOSIS, GENERATION, LIPIDS

Abstract

Docosahexaenoic acid (DHA) is an omega-3 fatty acid which has been demonstrated to exhibit anti-inflammatory effects. The objective of this study was to determine the effect of DHA on phagocytic and chemotactic activities of peritoneal macrophages obtained from rats. DHA was dissolved in 1 ml of corn oil at dose of 36 mg/kg/day and given via oral gavage for 4 weeks. Control rats received 1 ml/day corn oil as vehicle. At the end of the treatment period, peritoneal macrophages were isolated and chemotactic and phagocytic activities were assayed. Chemotactic and phagocytic activities were reduced in rats fed with DHA. These results demonstrated the effect of DHA in modulating immune activities of rat peritoneal macrophages. © 2007 Elsevier GmbH. All rights reserved.