Simultaneous determination of niclosamide and thiabendazole in tablets by second derivative spectrophotometry

ONUR F., Tekin N.

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.11, sa.1, ss.33-42, 1994 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 1994
  • Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.33-42
  • Anahtar Kelimeler: niclosamide, pharmaceutical preparations, second derivative spectrophotometry, simultaneous determination, thiabendazole
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Rapid second derivative spectrophotometric assay procedure is described for the simultaneous determination of niclosamide and thiabendazole in a pharmaceutical preparation. In this method the derivative absorbances were measured at 354,0 nm for niclosamide and at 242,5 nm for thiabendazole. The method has been applied succesfully to a tablet containing niclosamide and thiabendazole. The relative standard deviation of the method was found to be 1,19% for niclosamide and 0,51% for thiabendazole.