Simultaneous determination of niclosamide and thiabendazole in tablets by second derivative spectrophotometry

ONUR F., Tekin N.

Gazi Universitesi Eczacilik Fakultesi Dergisi, vol.11, no.1, pp.33-42, 1994 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 1994
  • Journal Name: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.33-42
  • Keywords: niclosamide, pharmaceutical preparations, second derivative spectrophotometry, simultaneous determination, thiabendazole
  • Lokman Hekim University Affiliated: No


Rapid second derivative spectrophotometric assay procedure is described for the simultaneous determination of niclosamide and thiabendazole in a pharmaceutical preparation. In this method the derivative absorbances were measured at 354,0 nm for niclosamide and at 242,5 nm for thiabendazole. The method has been applied succesfully to a tablet containing niclosamide and thiabendazole. The relative standard deviation of the method was found to be 1,19% for niclosamide and 0,51% for thiabendazole.