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Turk Anesteziyoloji ve Reanimasyon, vol.20, no.2, pp.73-76, 1992 (Scopus)
In this study; the haemodynamic, respiratory and sedative effects of oral midazolam (MDZ) premedication - when given alone or in combination with atropine - were evaluated and compared with IM pethidine+atropine (PET+ATR) premedication. 39 ASA I children scheduled for adenotonsillectomy aged between 3 and 10 years were randomly allocated to three groups. Group I received MDZ 0.3 mg/kg, po.: Group II, MDZ 0.3 mg/kg + ATR 0.01 mg/kg, po.; Group III, PET I mg/kg + ATR 0.01 mg/kg, IM 45 min before surgery. The level of sedation and salivation, response to IV cannulation were scored numerically and heart rate, arterial blood pressure and SaO2 were measured continuously. MDZ and MDZ + ATR groups had significantly better sedation scores and also significantly better response to IV cannulation. Salivation scores did not show any significant difference between MDZ and MDZ + ATR groups while PET + ATR group had significantly less salivation. There was not any significant change in heart rate in both of MDZ groups while increasing in PET+ATR group SaO2 levels were significantly low (remaining ~ 90%) in PET+ATR group when compared with both of MDZ groups. Respiratory rate did not show any significant change. It is concluded that; oral midazolam premedication is a safe and effective alternative to the previous forms of premedication in children, and atropine has no significant effect when combined with midazolam.