Comparison of oral midazolam, midazolam + atropine and IM pethidine + atropine premedications in children


KAHRAMAN S., Celiker V., AYPAR Ü.

Turk Anesteziyoloji ve Reanimasyon, vol.20, no.2, pp.73-76, 1992 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 1992
  • Journal Name: Turk Anesteziyoloji ve Reanimasyon
  • Journal Indexes: Scopus
  • Page Numbers: pp.73-76
  • Lokman Hekim University Affiliated: Yes

Abstract

In this study; the haemodynamic, respiratory and sedative effects of oral midazolam (MDZ) premedication - when given alone or in combination with atropine - were evaluated and compared with IM pethidine+atropine (PET+ATR) premedication. 39 ASA I children scheduled for adenotonsillectomy aged between 3 and 10 years were randomly allocated to three groups. Group I received MDZ 0.3 mg/kg, po.: Group II, MDZ 0.3 mg/kg + ATR 0.01 mg/kg, po.; Group III, PET I mg/kg + ATR 0.01 mg/kg, IM 45 min before surgery. The level of sedation and salivation, response to IV cannulation were scored numerically and heart rate, arterial blood pressure and SaO2 were measured continuously. MDZ and MDZ + ATR groups had significantly better sedation scores and also significantly better response to IV cannulation. Salivation scores did not show any significant difference between MDZ and MDZ + ATR groups while PET + ATR group had significantly less salivation. There was not any significant change in heart rate in both of MDZ groups while increasing in PET+ATR group SaO2 levels were significantly low (remaining ~ 90%) in PET+ATR group when compared with both of MDZ groups. Respiratory rate did not show any significant change. It is concluded that; oral midazolam premedication is a safe and effective alternative to the previous forms of premedication in children, and atropine has no significant effect when combined with midazolam.