Severe 25-OH vitamin D deficiency as a reason for adverse pregnancy outcomes

Kısa B., ÇELİK H., Candar T., Erol Koc E. M., Sert U. Y., Uzunlar O.

Journal of Maternal-Fetal and Neonatal Medicine, vol.33, no.14, pp.2422-2426, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.1080/14767058.2018.1554040
  • Journal Name: Journal of Maternal-Fetal and Neonatal Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.2422-2426
  • Keywords: 25-OH vitamin, adverse outcomes, first trimester, pregnancy, ASSOCIATION, SUPPLEMENTATION, RECOMMENDATIONS, WOMEN
  • Lokman Hekim University Affiliated: No


© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.Objective: There is a growing concern about the unfavorable effects of vitamin D deficiency in general population, including pregnant women, worldwide. The aim of this study is to evaluate the effect of severe maternal serum 25-OH vitamin D levels on adverse pregnancy outcomes in first trimester. Material and methods: Serum samples of 86 pregnant women in first trimester were collected prospectively from May 2017 to June 2017. Serum 25-OH vitamin D levels were analyzed by enzyme immunoassay method. Patients were classified according to maternal serum 25-OH vitamin D levels as group 1 (n = 34) <10 ng/ml and group 2 (n = 52) >10 ng/ml. The two groups were compared in terms of adverse pregnancy outcomes. Results: The mean 25-OH vitamin D levels of the total 86 pregnant women were 13.83 (6–48) ng/ml. 40% of the pregnant women had low level of 25-OH vitamin D levels (<10 ng/ml). The adverse pregnancy outcomes were significantly increased in group 1 (p<.018). Conclusions: Maternal serum 25-OH vitamin D levels <10 ng/ml is a risk factor for adverse pregnancy outcomes. 25-OH vitamin D levels should be screened in high-risk pregnant women and treated in case of deficiency.