Three new spectrophotometric methods for simultaneous determination of hydrochlorothiazide and amiloride hydrochloride in sugar-coated tablets

ERK N., ONUR F.

Analytical Letters, vol.30, no.8, pp.1503-1515, 1997 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 8
  • Publication Date: 1997
  • Doi Number: 10.1080/00032719708001671
  • Journal Name: Analytical Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1503-1515
  • Keywords: Amiloride hydrochloride, Hydrochlorothiazide, Pharmaceutical preparations, Simultaneous determination, Spectrophotometry
  • Lokman Hekim University Affiliated: No

Abstract

Three new spectrophotometric methods, Vierordt's method, its modified version and the absorbancy ratio method have been used for the simultaneous determination of hydrochlorothiazide and amiloride hydrochloride in binary mixtures. Mean recoveries, relative standard deviations and linearity ranges in calibration graphs of the methods were compared. These three methods have been successfully applied to a commercial pharmaceutical preparation, a sugar-coated tablet containing hydrochlorothiazide and amiloride hydrochloride.