Overcoming the challenges of drug resistance through combination drug delivery approach

TONBUL H., ŞAHİN A., ÇAPAN Y.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases, Elsevier, ss.31-46, 2022 identifier

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/b978-0-323-85873-1.00003-4
  • Yayınevi: Elsevier
  • Sayfa Sayıları: ss.31-46
  • Anahtar Kelimeler: combination drug delivery, Drug resistance, nanoparticles
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Anticancer and antimicrobial drug resistances are the most important problems that decrease the overall success of drug treatment in the clinic. The combination of two or more different kinds of drugs in clinical practice has been generally accepted as a feasible strategy to achieve superior therapeutic efficacy. However, codelivery of drugs in free form may fail due to different solubility, pharmacokinetic behavior, and stability problems. Drug delivery systems, mainly nanoparticulate systems, hold the big potential to achieve this problem. In this chapter, different approaches used in combination therapy to overcome drug resistance are discussed.