The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury

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TUĞLU D., Yuvanc E., Yılmaz E., Gencay I. Y., Atasoy P., Kisa U., ...Daha Fazla

Acta Cirurgica Brasileira, cilt.30, sa.6, ss.414-421, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1590/s0102-865020150060000007
  • Dergi Adı: Acta Cirurgica Brasileira
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.414-421
  • Anahtar Kelimeler: Dexmedetomidine, Spermatic Cord Torsion, Antioxidants, Reperfusion Injury, Testis, Rats, INFLAMMATORY RESPONSES, RAT-KIDNEY, TORSION, THERAPY, TISSUE, SHOCK, MICE
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2015, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.Purpose: To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats. Methods: Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 μg/kg Dex (group 3) and 100 μg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. Results: Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 μg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 μg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations. Conclusion: The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen’s scoring system between groups at both sides.