The effects of atorvastatin and rosuvastatin on oxidative stress in diabetic patients

Koksal M., Eren M. A., Turan M. N., Sabuncu T.

European Journal of Internal Medicine, vol.22, no.3, pp.249-253, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.ejim.2010.12.003
  • Journal Name: European Journal of Internal Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.249-253
  • Keywords: Hyperlipidemia, Oxidative stress, Statin, Type 2 diabetes mellitus
  • Lokman Hekim University Affiliated: No


Aim: Diabetes is associated with abnormalities in lipid profile and increased oxidative stress. Statins are preferred agents in diabetic patients due to their antioxidant and LDL-C lowering effects. This study is designed to compare the effects of atorvastatin and rosuvastatin on low density lipoprotein cholesterol (LDL-C), lipid hydroperoxide (LOOH), total oxidant status (TOS) and total antioxidant capacity (TAC) in diabetic patients with hyperlipidemia. Materials and methods: Sixty two patients who have type 2 diabetes mellitus with serum LDL levels more than 100 mg/dL were randomly assigned to receive atorvastatin 20 mg (n = 31) or rosuvastatin 10 mg (n = 31). Blood tests were performed at the beginning of the study and after three months. Results: There were no statistically significant differences in the pre- and after treatment levels of the LDL-C between groups. TAC values were increased in both groups and statistically significant in the former group (p = 0.007). There was no diferrence between the change percentages ((after treatment TAC - pretreatment TAC) / pretreatment level) of TAC between two treatment groups. The effects of two drugs on the other oxidative parameters were not significantly different. Conclusion: Both atorvastatin and rosuvastatin may be helpful in reducing increased oxidative stress in diabetic patients with hyperlipidemia. © 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.