Influence of CPAP treatment on airway and systemic inflammation in OSAS patients

Karamanli H., Ozol D., Ugur K. S., Yildirim Z., Armutcu F., Bozkurt B., ...More

SLEEP AND BREATHING, vol.18, no.2, pp.251-256, 2014 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1007/s11325-012-0761-8
  • Journal Name: SLEEP AND BREATHING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.251-256
  • Keywords: Sleep apnea, CPAP, Inflammation, Oxidative stress, OBSTRUCTIVE SLEEP-APNEA, EXHALED BREATH CONDENSATE, PRACTICE PARAMETERS, NITRIC-OXIDE
  • Lokman Hekim University Affiliated: No

Abstract

Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent respiratory disorders in the upper airways during sleep. Although continuous positive airway pressure (CPAP) has been accepted to be the most effective treatment for OSAS, its role on inflammation remains debatable. In this study, our aim was to examine the influence of 3 months of CPAP treatment on tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 8-isoprostane, and peroxynitrite levels in exhaled breathing condensates (EBC) and serum.