Simultaneous determination of active ingredients in suppositories containing paracetamol by first derivative UV spectrophotometry

ONUR F., ACAR N.

S.T.P. Pharma Sciences, cilt.5, sa.2, ss.152-155, 1995 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 2
  • Basım Tarihi: 1995
  • Dergi Adı: S.T.P. Pharma Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.152-155
  • Anahtar Kelimeler: PARACETAMOL, PHENOBARBITAL, ACETYLSALICYLIC ACID, FIRST DERIVATIVE SPECTROPHOTOMETRY, PHARMACEUTICAL PREPARATION, LIQUID-CHROMATOGRAPHY, ACETAMINOPHEN, CAFFEINE
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

In this paper, rapid first derivative UV spectrophotometric assay procedures are described for the simultaneous determination of paracetamol, phenobarbital and acetylsalicylic acid in their binary mixtures. The methods have been successfully applied to the suppositories containing paracetamol phenobarbital and paracetamol acetylsalicylic acid combinations. The relative standard deviation was found to be 0.28% for paracetamol at 263.2 nm and 0.66% for phenobarbital at 218.2 nm in the first combination, and 0.48% for paracetamol at 255.8 nm and 0.64% for acetylsalicylic acid at 218.6 nm in the second combination.