Urinary methylmalonic acid levels in patients with acute ischemic stroke


Kara N., Senes M., Coskun O., Inan L., Saydam G., Yucel D.

CLINICAL BIOCHEMISTRY, vol.42, no.7-8, pp.578-583, 2009 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 7-8
  • Publication Date: 2009
  • Doi Number: 10.1016/j.clinbiochem.2009.02.018
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.578-583
  • Keywords: Folic acid, Homocysteine, Ischemic stroke, Methylmalonic acid, Vitamin B-12, FOLIC-ACID, FOLATE-DEFICIENCY, VITAMIN-B-12 DEFICIENCY, CARDIOVASCULAR-DISEASE, LIQUID-CHROMATOGRAPHY, COBALAMIN DEFICIENCY, PLASMA HOMOCYSTEINE, SERUM COBALAMIN, OLDER PERSONS, RISK

Abstract

Objectives: Vitamin B-12 and folate deficiency are common, especially in people aged 55 or over, and accompanied by elevated methylmalonic acid (MMA) and homocysteine concentrations. The aims of the study were to investigate the relationship between serum vitamin B-12, homocysteine, folate, erythrocyte folate and urinary MMA in patients with ischemic stroke, and to develop a simple screening HPLC method for the measurement of urinary MMA.