Urinary methylmalonic acid levels in patients with acute ischemic stroke

Kara N., Senes M., Coskun O., Inan L., Saydam G., Yucel D.

CLINICAL BIOCHEMISTRY, vol.42, no.7-8, pp.578-583, 2009 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 42 Issue: 7-8
  • Publication Date: 2009
  • Doi Number: 10.1016/j.clinbiochem.2009.02.018
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.578-583
  • Keywords: Folic acid, Homocysteine, Ischemic stroke, Methylmalonic acid, Vitamin B-12, FOLIC-ACID, FOLATE-DEFICIENCY, VITAMIN-B-12 DEFICIENCY, CARDIOVASCULAR-DISEASE, LIQUID-CHROMATOGRAPHY, COBALAMIN DEFICIENCY, PLASMA HOMOCYSTEINE, SERUM COBALAMIN, OLDER PERSONS, RISK
  • Lokman Hekim University Affiliated: No

Abstract

Objectives: Vitamin B-12 and folate deficiency are common, especially in people aged 55 or over, and accompanied by elevated methylmalonic acid (MMA) and homocysteine concentrations. The aims of the study were to investigate the relationship between serum vitamin B-12, homocysteine, folate, erythrocyte folate and urinary MMA in patients with ischemic stroke, and to develop a simple screening HPLC method for the measurement of urinary MMA.