Serum prolidase activity is associated with non-diabetic metabolic syndrome


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Tabur S., Oguz E., Eren M. A., Korkmaz H., Savas E., Aksoy N., ...More

Diabetology and Metabolic Syndrome, vol.6, no.1, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1186/1758-5996-6-142
  • Journal Name: Diabetology and Metabolic Syndrome
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Metabolic syndrome, Non-diabetic, Obesity, Prolidase
  • Lokman Hekim University Affiliated: No

Abstract

Objective: The aim of this study was to determine the role of serum prolidase activity and the possible association with oxidative stress parameters in non-diabetic metabolic syndrome. Methods: 30 obese patients without metabolic syndrome (MetS), 34 non-diabetic obese patients with MetS, and 23 volunteer control subjects were enrolled in the study. Fasting plasma glucose (FPG), plasma glucose following 75 g glucose administration, high-density lipoprotein-cholesterol (HDL-C), high-density lipoprotein-cholesterol (LDL-C), total cholesterol, triglyceride (TG), total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and prolidase activities of all subjects were analyzed. Results: Prolidase levels was significantly higher in MetS group compared to both obese and control groups (p < 0.001 and p < 0.05 respectively). Prolidase was also higher in the obese group than in the control group (p < 0.05). Prolidase was negatively correlated with TAS and HDL-C (r =-0,362, p < 0.001; r =-0.320, p < 0.01, respectively) and positively correlated with BMI, weight, waist-c, SBP, DBP, TG, TC, LDL-C. Conclusion: Prolidase activity may have a role in the pathogenesis of metabolic syndrome.