Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.28, sa.6, ss.828-833, 2008 (Scopus)
Objective: The human skin is one of the major organs in continuous interaction with environmental factors. The effects Of frostbite on the skin have been extensively studied and many drugs for its treatment have been tested over the years. The effects of melatonin in the treatment of tissue injuries have also investigated. The present study was periftrned to examine.t~e effects ofmelatorim on frostbite of tkeskin. Materialand Methods: This study was performed in-2006 in the Anatomy Department of Hacettepe Univqrsity, Faculty of Medicine. Ears offive rabbits were used in each9roupand specimenswere taken bypunch biopsy. Groups were allocated as follows: Control group: - rabbit ears with no induced injury or treatment; Trauma group: rabbit ears subjected to cold injury; Treatment group: rabbit ears treated with melatonin after cold injury; imd Sham gro- up: rabbit ears treated with 0.9% NaCI after cold inIury. Specimens were evaluated,by transmission electron microscope and were scored statistically. Results: In the tta'arria group, the cells of the stratum corheurrilayer of the epidermis had separated. Intra-cytoplasmic edema and vacuoles in these cells were visible. Although there was loss ofcbromatin and evident edema in the nucleus of some of these cells, there was no clear defect in the distributio n of the nuclear chromatin in general. Separation between the cells of the stratum corneurn of the melato- nin group was absent. The cells were normal, collagen fibers were regular and the fibroblasts were inactive. Conclusion: The results obtained in this rabbit model are significant for suggesting the favorable effects of melatonin on cold injury. Copyright © 2008 by Türkiye Klinikleri.