Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: Potential biomarkers for a subclinical nephrotoxicity

Orhan H., Sahin A., Sahin G., AYPAR Ü., Vermeulen N. P.

Biomarkers, vol.18, no.1, pp.73-81, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.3109/1354750x.2012.737026
  • Journal Name: Biomarkers
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-81
  • Keywords: Acetone, Aldehydes, Clinical markers, Dityrosine, Tubular damage
  • Lokman Hekim University Affiliated: Yes


Objective: To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. Methods: Urine and blood samples were collected from patient groups. Excretion of aldehydes, acetone, and o,o'-dityrosine was measured before and after anesthesia. Blood samples were analysed for clinical markers. Results: Urinary concentrations of aldehydes, acetone, o,o'-dityrosine and glucose were significantly increased after anesthesia in halothane and sevoflurane groups earlier than clinical markers. Significant correlations were found in sevoflurane group. Conclusion: Lipid and protein oxidation contributes to subclinical sevoflurane nephrotoxicity. Oxidation products may serve as early biomarkers. © 2013 Informa UK, Ltd.