Akademik Veri Yönetim Sistemi
European Surgical Research, cilt.30, sa.3, ss.205-213, 1998 (SCI-Expanded)
It is a well-known fact that laparoscopic procedures performed with carbon dioxide insufflation impair myocardial function. In this study, we aimed to determine the safety limitations of various intra-abdominal pressure values during abdominal insufflation with carbon dioxide. Of the 24 mongrel dogs, 6 were assigned to one of four different pressure groups (10, 15, 20 and 30 mmHg), respectively. Cardiac output, right/left heart pressures, and the first derivative of ventricular pressure were monitored. Myocardial oxygen consumption, myocardial lactate/oxygen extraction, tissue lactate and adenosine triphosphate levels were determined. Measurements were performed initially as a control, at 15-min intervals during 1 h of insufflation and 1 h after desufflation. At 10 mmHg carbon dioxide pressure, hemodynamic and metabolic parameters were not significantly different. Cardiac output decreased significantly in the 20 and 30 mmHg groups (p < 0.05: 10, 15 vs. 20, 30 mmHg). Although cardiac output did not change at 15 mmHg, the dp/dt value was significantly reduced. Cardiac output at the 60th min was 1960 ± 75 ml/min in the 10 mmHg group, 1885 ± 40 ml/min in the 15 mmHg group, 1770 ± 45 ml/min in the 20 mmHg group and 1695 ± 40 ml/min in the 30 mmHg group. Myocardial oxygen consumption was reduced at 15, 20 and 30 mmHg (p < 0.05: 10 vs. 15, 20 and 30 mmHg). In the myocardial tissue, ATP decreased from 19 ± 2 to 12 ± 1.2 μmol/g at 15 mmHg, from 19 ± 1.9 to 9.4 ± 1.3 μmol/g at 20 mmHg and from 18 ± 3.2 to 8.2 ± 1.9 μmol/g at 30 mmHg. Changes in hemodynamic and metabolic parameters of the heart are reversible and may not lead to any significant impairments in patients having normal cardiopulmonary function, but pose a risk in patients with respiratory disease and limited myocardial reserve.