Cyclosporin A (CsA) + methylprednisone (MP) and antilymphocyte globulin + methylprednisone (MP) therapy in patients with aplastic anemia: Ibn-i Sina Hospital experience

İLHAN ., Koc H., Beksac M., Akan H., Aydogdu I., Konuk N., ...More

Bulletin of Gulhane Military Medical Academy, vol.35, no.4, pp.893-897, 1993 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 1993
  • Journal Name: Bulletin of Gulhane Military Medical Academy
  • Journal Indexes: Scopus
  • Page Numbers: pp.893-897
  • Keywords: Aplastic anemia, Immunosuppressive therapy
  • Lokman Hekim University Affiliated: Yes

Abstract

Twenty-one patients with aplastic anemia (AA) were evaluated for the outcome of immunosuppressive therapy. Six severe (ANC < 500/mm3) and 5 less severe (ANC > 500/mm3) AA patients received cyclosporin A (CsA) and methylprednisone (MP) with CsA serum levels monitorization. Ten less severe AA patients were given antilymphocyte globulin (ALG) and MP. The mean follow-up period was 11.8 (2-36) months for patients who received CsA + MP and 3 (2-4) months for ALG + MP. The response rates in patients who received CsA was 45% (3 complete remission (CR), two partial remission (PR)). In ALG + MP group there was 4 PR (40%). Five CsA + MP patients (+6, +22, +24, +24, +36 months) and 4 ALG + MP patients (+2, +3, +4, +4 months) are still in remission. CsA exerted substantial but reversible side effects. In one patient who received ALG + MP hypertension and nephrotoxicity that necessitated drug withdrawal was observed. Although the results seem to be early, combination of CsA + MP is better than ALG + MP in this non-randomized study.