Formulation and efficacy of sustained-release theophylline tablets

ÇAPAN Y., Capan N., Kas H., Atikcan S., Baser Y., Hincal A.

S.T.P. Pharma Sciences, vol.2, no.2, pp.169-173, 1992 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 2
  • Publication Date: 1992
  • Journal Name: S.T.P. Pharma Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.169-173
  • Lokman Hekim University Affiliated: No


To determine the influence of diluents and the percent of matrix material on the formulation of sustained-release tablets, in vitro release of theophylline was studied. Sustained-release tablets were formulated using hydroxypropyl methylcellulose as matrix and dibasic calcium phosphate dihydrate and lactose as the diluents. The formulation containing 20% hydroxypropyl methylcellulose and lactose showed a sustained-release profile comparable to that of a standard commercially-available sustained-release tablet containing 200 mg of theophylline embedded in the matrix. The formulated and commercially-available standard sustained-release tablets and sustained-release capsules are administered to eighteen patients with bronchial asthma. These studies showed that the sustained-release preparations produced an improvement in the pulmonary function parameters such as forced vital capacity, forced expiratory volume in the first second and peak expiratory flow rate. No significant pharmacodynamic differences between these sustained release preparations could be demonstrated.