First derivative spectrophotometric determination of cefixime and cefdinir in pharmaceutical preparations Sefdinir ve sefiksim'in farmasötik preparatlarda birinci tiirev spektrofotometrik tayini

Baş E., Özdem S., ÇAĞLAYAN M. G., PALABIYIK İ. M., ONUR F.

Turkish Journal of Pharmaceutical Sciences, cilt.10, sa.3, ss.321-328, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2013
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.321-328
  • Anahtar Kelimeler: Cefdinir, Cefixime, First derivative spectrophotometry, Pharmaceutical preparations
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

In this study, a first derivative spectrophotometric method was developed for the determination of cefdinir and cefixime in pharmaceutical preparations. Cefdinir and cefixime were dissolved in 0.1 M Na2HPO4 (pH 8.0) and dA/dX values were measured at 306.8 nm for cefdinir and 307.0 nm for cefixime in their first derivative spectra. Cefdinir and cefixime obey Beer's Law in the range of 2-30 μg/mL (r=0.9993) and 2.5-35 μg/mL (r=0.9997) respectively. LOD values were 0.28 μg/mL and 0.45 μg/mL and LOQ values were 0.98 μg/mL and 1.50 μg/mL for cefdinir and cefixime respectively. Method was validated and successfully applied to tablet formulations marketed in Turkey. The results were compared with an previously developed HPLC method.