First derivative spectrophotometric determination of cefixime and cefdinir in pharmaceutical preparations Sefdinir ve sefiksim'in farmasötik preparatlarda birinci tiirev spektrofotometrik tayini

Baş E., Özdem S., ÇAĞLAYAN M. G., PALABIYIK İ. M., ONUR F.

Turkish Journal of Pharmaceutical Sciences, vol.10, no.3, pp.321-328, 2013 (SCI-Expanded, Scopus, TRDizin) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2013
  • Journal Name: Turkish Journal of Pharmaceutical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.321-328
  • Keywords: Cefdinir, Cefixime, First derivative spectrophotometry, Pharmaceutical preparations
  • Lokman Hekim University Affiliated: No

Abstract

In this study, a first derivative spectrophotometric method was developed for the determination of cefdinir and cefixime in pharmaceutical preparations. Cefdinir and cefixime were dissolved in 0.1 M Na2HPO4 (pH 8.0) and dA/dX values were measured at 306.8 nm for cefdinir and 307.0 nm for cefixime in their first derivative spectra. Cefdinir and cefixime obey Beer's Law in the range of 2-30 μg/mL (r=0.9993) and 2.5-35 μg/mL (r=0.9997) respectively. LOD values were 0.28 μg/mL and 0.45 μg/mL and LOQ values were 0.98 μg/mL and 1.50 μg/mL for cefdinir and cefixime respectively. Method was validated and successfully applied to tablet formulations marketed in Turkey. The results were compared with an previously developed HPLC method.