The outcome of adding peripheral neuromodulation (stoller afferent neuro-stimulation) to anti-muscarinic therapy in women with severe overactive bladder

Sancaktar M., Ceyhan S. T., Akyol I., Muhcu M., ALANBAY İ., Ercan C. M., ...More

Gynecological Endocrinology, vol.26, no.10, pp.729-732, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.3109/09513591003649815
  • Journal Name: Gynecological Endocrinology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.729-732
  • Keywords: Peripheral neuromodulation, anti-muscarinic treatment, quality of life, overactive bladder, URINARY-INCONTINENCE, DETRUSOR INSTABILITY, URGE INCONTINENCE, NERVE-STIMULATION, QUESTIONNAIRE, DIAGNOSIS, INDEX
  • Lokman Hekim University Affiliated: No


Objective. Anti-muscarinic treatment alone and peripheral neuromodulation with concomitant anti-muscarinic treatment were compared in patients with severe overactive bladder. Methods.In this prospective study, 40 women with severe overactive bladder according to the 7-day voiding diary without any prior treatment completed the Incontinence Impact Questionnaire (IIQ-7) and were randomised into anti-muscarinic-alone and combination treatment groups. Twenty women received daily 4 mgs of tolterodine orally and in 20 women Stoller afferent neuro-stimulation (SANS) therapy was performed concomitantly for 12 weeks to the same anti-muscarinic regimen. After 12 weeks of therapy, two of the patients drop out of the study and remaining patients filled out the IIQ-7 questionnaire and the 7-day voiding diary again. Pretreatment and post-treatment QoL scores and the 7-day voiding diaries were compared. MannWhitney U, Wilcoxon and two sided significance tests were used. Results.Thirty-eight women fulfilling the criteria were included in the study. Severity of overactive bladder symptoms decreased significantly in both treatment groups. However, the decrease in combination treatment group was more significant than the anti-muscarinic-alone group. Adverse events were similar between the two groups. Conclusion.Combining SANS and anti-muscarinic therapy resulted in significantly better clinical outcomes and IIQ-7 scores as compared with anti-muscarinic treatment alone in patients with severe overactive bladder. © 2010 Informa UK, Ltd.