Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction

HAN S., BAL N. B., SADİ G., USANMAZ S. E., Tuglu M. M., ULUDAĞ M. O., ...More

VASCULAR PHARMACOLOGY, vol.113, pp.38-46, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 113
  • Publication Date: 2019
  • Doi Number: 10.1016/j.vph.2018.11.004
  • Journal Name: VASCULAR PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.38-46
  • Keywords: Hypertension, Endoplasmic reticulum stress, Vascular dysfunction, TUDCA, GROWTH-FACTOR RECEPTOR, SMOOTH-MUSCLE-CELLS, ENDOTHELIAL DYSFUNCTION, OXIDATIVE STRESS, ANTIOXIDANT STATUS, TYROSINE KINASE, CARDIAC DAMAGE, BLOOD-PRESSURE, ER STRESS, RESISTANCE
  • Lokman Hekim University Affiliated: No

Abstract

Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated. Endoplasmic reticulum stress (ERS), which is a condition of the unfolded/misfolded protein accumulation in the endoplasmic reticulum, has been defined as a potential target for cardiovascular disease. In the present study, the effects of ERS inhibition on hypertension-induced alterations in the vessels were investigated.