The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease.


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Tural R., Altan N., Irkec C., Sahin D., Batur Caglayan H. Z.

Bratislavske lekarske listy, vol.121, no.11, pp.812-816, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_133
  • Journal Name: Bratislavske lekarske listy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.812-816
  • Keywords: Alzheimer disease, diabetes mellitus, insulin, IGF-1, amyloid beta (A beta), sirtuin 1 (SIRT1), leptin, GROWTH-FACTOR-I, LEPTIN, RESTRICTION, DYSFUNCTION, PATHOLOGY, TAU
  • Lokman Hekim University Affiliated: No

Abstract

Objective: Recent evidence suggests that insulin resistance may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, the probable role of insulin resistance in the pathogenesis of AD was investigated in patients with Type 2 Diabetes Mellitus (T2DM).