Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.23, sa.4, ss.219-225, 2015 (Scopus)
Objective: In this prospective, randomized study, we compared the effects on standard coagulation parameters of the standard Lactated Ringer (LR) priming solution with the latest generation of hydroxyethyl starch solutions, HES (130/0.4). Method: Twenty patients with cyanotic heart disease aged between 6 months and 10 years were included. A LR solution was used as a priming solution in group I, and in group II, a HES (130/0.4) solution was used. Demographic and clinical data (age, sex, weight, duration of operation, cardiopulmonary bypass (CPB), and aortic cross-clamping time), duration of ICU stay, and hospitalization time were also recorded. Laboratory parameters of blood samples were collected after anesthesia induction (T1),five minutes after heparinization (T2), ten minutes after the initiation of CPB (T3), after weaning from CPB and protamine administration (T4), at 24 hours postoperatively (T5), and at 48 hours postoperatively (T6) in all patients. Hematocrit, hemoglobin, and platelet counts were recorded at T1-6. Coagulation parameters (international normalized ratio, activated partial thromboplastin time) and liver function tests were analyzed at T1 and T4-6. Total fluid administration, urine output, fresh frozen plasma and erythrocyte suspension amount, inotropic and diuretic requirements, and chest tube drainage amount were recorded at the end of the operation and 24 and 48 hours postoperatively in all patients. Results: Hemoglobin (gldL) and hematocrit levels, platelet count and activated partial thromboplastin time values did not differ significantly between groups. There was also no statistically significant difference in usage of inotropic and diuretic agents, postoperative drainage from chest tube, total urine output, fluid administration, or amount of red blood cells or fresh frozen plasma used. Although international normalized ratio values increased in both groups at different times compared to the baseline levels (Tl) (p < 0.05), there was no significant difference between two groups. Conclusion: We concluded that HES (13010.4) solution does not affect the standard coagulation parameters of children with cyanotic heart diseases undergoing CPB.