Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.11, sa.4, ss.260-264, 2003 (Scopus)
The aim of this study was to compare the effects of halothane, isoflurane and sevoflurane on immune response. 35 patients ASA grade I-II scheduled to undergo laparoscopic cholecystectomy were included in the study. Patients were randomly allocated into three groups according to the inhalation agents used (halothane n:12, isoflurane n:12, sevoflurane n:11). In all groups, general anesthesia was induced with thiopentone, vecuronium and fentanyl and maintained with 50 % N2O in oxygen and one of the three volatile agents [Group I: halothane (Group H), Group II: isoflurane (Group I) and Group III: sevoflurane (Group S)]. Blood samples were taken before induction and skin incision, at the end of surgery and, 24 hours postoperatively, to determine serum IgA, IgG, IgM, IL-2 and IL-6 levels. The changes in immunologic parameters according to time were similar in all groups. Serum IgA, IgG and IgM levels showed a significant decrease before incision and at the end of surgery where serum IL-2 levels showed a significant decrease before incision in all groups. Serum IL-6 levels showed a significant increase after surgery and 24 hours postoperatively in all groups. As a result, this significant immune supression was thought to be the primary effect of surgical trauma rather than the effect of halothane, isoflurane and sevoflurane and these three volatil anesthetics had basically similar effects on serum immunoglobulin and cytokine levels.