Simultaneous determination of methylene blue, hexamethylene tetramine and resorcinol in pharmaceutical formulations by first-derivative UV spectrophotometry
International Journal of Pharmaceutics, vol.78, no.1-3, pp.89-91, 1992 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 78 Issue: 1-3
- Publication Date: 1992
- Doi Number: 10.1016/0378-5173(92)90359-a
- Journal Name: International Journal of Pharmaceutics
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.89-91
- Keywords: SIMULTANEOUS DETERMINATION, 1ST DERIVATIVE SPECTROPHOTOMETRY, METHYLENE BLUE, HEXAMETHYLENE TETRAMINE, RESORCINOL, PHARMACEUTICAL FORMULATION
- Lokman Hekim University Affiliated: No
Abstract
In this paper, rapid and precise first-derivative UV spectrophotometric assay procedures are described for the simultaneous determination of methylene blue, hexamethylene tetramine and resorcinol in their binary mixtures. The methods have been applied successfully to a dragee containing methylene blue-hexamethylene tetramine and a mouth-wash formulation containing methylene blue-resorcinol combinations. The relative standard deviation was found to be 0.71% for methylene blue at 273.0 nm and 0.70% for hexamethylene tetramine at 221.3 nm in the first combination and 0.21% for methylene blue at 300.0 nm and 0.54% for resorcinol at 260.4 nm in the second combination. © 1992.