Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-fam catalyst
Journal of Organic Chemistry, cilt.73, sa.18, ss.7373-7375, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 18
- Basım Tarihi: 2008
- Doi Numarası: 10.1021/jo8010073
- Dergi Adı: Journal of Organic Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.7373-7375
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
(Chemical Equation Presented) Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, α,β-unsaturated, and heteroaromatic) and α-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be recovered and recycled without losing its activity. © 2008 American Chemical Society.