Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-fam catalyst

BULUT A., Asian A., DOĞAN Ö.

Journal of Organic Chemistry, cilt.73, sa.18, ss.7373-7375, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 18
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1021/jo8010073
  • Dergi Adı: Journal of Organic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7373-7375
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

(Chemical Equation Presented) Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, α,β-unsaturated, and heteroaromatic) and α-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be recovered and recycled without losing its activity. © 2008 American Chemical Society.