Relationship between high sensitivity troponins and estimated glomerular filtration rate


Guclu T., Bolat S., Şenes M., Yucel D.

Clinical Biochemistry, vol.49, no.6, pp.467-471, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1016/j.clinbiochem.2015.12.012
  • Journal Name: Clinical Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.467-471
  • Keywords: Acute coronary syndrome, Cardiac troponin, Chronic kidney disease, Creatinine, Estimated glomerular filtration rate, CHRONIC KIDNEY-DISEASE, ACUTE CORONARY SYNDROME, CARDIAC TROPONIN, HEMODIALYSIS-PATIENTS, RENAL-INSUFFICIENCY, BIOMARKERS, PREDICTORS, MORTALITY, FAILURE
  • Lokman Hekim University Affiliated: No

Abstract

© 2016 The Canadian Society of Clinical Chemists.Background: Diagnosis of acute coronary syndrome may be challenging because of high troponin concentrations in patients with chronic kidney disease. Objective: the aim of this study is to investigate the difference between high sensitivity troponin T and troponin I in four groups of patients separated according to eGFR values and the effect of renal function both on troponin T and troponin I. Methods: 119 outpatients were divided into 4 groups according to their eGFR values as Group 1: eGFR < 30, Group 2: eGFR between 30 and 60, Group 3: eGFR between 60 and 90 and Group 4: eGFR >90 mL/min/1.73 m2. The cardiac troponin T and I concentrations were measured concurrently. Results: Troponin T values of all patients who have eGFR values lower than 30 mL/min/1.73 m2 were above the decision point, but cTnI values of only 2 patients were above the decision limit (40 ng/L) in this group. There was a strong and significant negative relationship between eGFR and hs-cTnT [log(y) = 2.3-0.72log(x); R2 = 0.625] whereas there was no significant relationship between eGFR and hs-cTnI [log(y) = 1.28-0.08log(x); R2 = 0.013] when eGFR was taken into consideration as a continuous variable. Conclusion: In this study, we found that cTnT increases with decreasing eGFR values, but cTnI is not affected by the change in eGFR values.