Akademik Veri Yönetim Sistemi
Vaccine, cilt.20, sa.25-26, ss.3052-4, 2002 (SCI-Expanded)
Thyphoid fever is a disease predominant in underdeveloped and developing countries. Thyphoid fever is more prevalent, in fact endemic, in countries where fecal contamination of water and food sources are very common. The majority of the reported cases are in the adult age group. There are three different vaccines which can be used to prevent thyphoid fever. In this study, we have used the parenteral Vi vaccine which was developed using the polisaccharide Vi antigen that covers the bacteria's surface, thus, concealing the 0 antigen protecting the bacteria against Anti-O antibodies and regarded as virulence factor. A total of 110 individuals whose sera were negative for seroconversion prior to vaccination were included in this study in which we have assessed Anti-Vi antibodies by tube agglutination. Serum and stool samples of 110 individuals were assessed 1 month after the vaccination. A total of 105 (95.5%) of the vaccinated people were considered to have positive (1/40 and higher) response and this result was regarded as prophylactic seroconversion. None of the people in the study group had Salmonella typhi, S. paratyphi A,B,C isolated from their stool cultures. (C) 2002 Elsevier Science Ltd. All rights reserved.