Antimicrobial prenylated benzoylphloroglucinol derivatives and xanthones from the leaves of Garcinia goudotiana

Mahamodo S., Rivière C., Neut C., Abedini A., Ranarivelo H., Duhal N., ...Daha Fazla

Phytochemistry, cilt.102, ss.162-168, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.phytochem.2014.03.006
  • Dergi Adı: Phytochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.162-168
  • Anahtar Kelimeler: Garcinia goudotiana, Clusiaceae Madagascar, Benzoylphloroglucinol derivatives, Xanthones, Antimicrobial activities, Cytotoxic activities, NATURAL-PRODUCTS, BENZOPHENONES, CONSTITUENTS, BRASILIENSIS, BIFLAVONOIDS, BARK
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Bioassay-guided fractionation using antimicrobial assay of the crude acetonic extract of Garcinia goudotiana leaves and of its five partitions led to the isolation of two new prenylated benzoylphloroglucinol derivatives, goudotianone 1 (1) and goudotianone 2 (2), in addition to two known compounds including one xanthone, 1,3,7-trihydroxy-2-isoprenylxanthone (3), and one triterpenoid, friedelin (4). Their structures were elucidated on the basis of different spectroscopic methods, including extensive 1D- and 2D-NMR spectroscopy and mass spectrometry. The crude acetonic extract, the methylene chloride and ethyl acetate partitions, and some tested compounds isolated from this species (1-3) demonstrated selective significant antimicrobial activities against Gram-positive bacteria, in particular Staphylococcus lugdunensis, Enterococcus faecalis and Mycobacterium smegmatis. The potential cytotoxic activities of these extracts and compounds were evaluated against human colon carcinoma HT29 and human fetal lung fibroblast MRC5 cells. © 2014 Elsevier Ltd. All rights reserved.