Research Information System
Anestezi Dergisi, vol.12, no.3, pp.175-179, 2004 (Scopus)
The effects of midazolam and combination of midazolam with fentanyl and/or propofol on sedation, hemodynamic parameters, postoperative satisfaction and side effects were investigated. Group M received only midazolam 0.02 mg kg-1, group MP midazolam 0.02 mg kg-1 + propofol 0.2 mg kg-1, group MF midazolam 0.02 mg kg-1 + fentanyl 1 μg kg-1, group MPF midazolam 0.02 mg kg-1 + propofol 0.2 mg kg-1 + fentanyl 1 μg kg-1. The sedation levels of patients were measured according to a physician questionnaire. Postoperative nausea/vomiting, headache and patient satisfaction were determined via a patient evaluation scale. In the groups receiving fentanyl, the hemodynamic response to peribulber block insertion (PBI) was minimal (p<0.05). The respiration rate and O2 saturation of patients receiving midazolam, propofol and fentanyl decreased after sedation (p<0.01). Patients in the midazolam group showed a prominent reaction to PBI and movement during the operation was significant in this group (p<0.05). The sedation level was the best in the groups receiving fentanyl (p<0.05). Postoperative satisfaction was high in patients receiving midazolam, propofol and fentanyl (p< 0.01). As a conclusion, the combination of midazolam, propofol and fentanyl may be preferred to only midazolam or midazolam+propofol or midazolam+fentanyl combinations with paying attention to the risk of desaturation.