Assessment of the effects of hypertonic saline and hydroxyethyl starch on hemodynamic parametres and coagulation for hypervolemic hemodilution Hipervolemik hemodilüsyonda, hipertonik (% 3'lük) NaCL solüsyonu ve % 6'lık hidroksi etil nişasta 130/0,4'ün hemodinami ve koagülasyon etkilerinin deǧerlendirilmesi

AKINCI S. B., SARICAOĞLU F., Dal D., Erem Y., ATİLLA B., Özcebe O., ...More

Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, vol.37, no.5, pp.287-295, 2009 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 5
  • Publication Date: 2009
  • Journal Name: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.287-295
  • Keywords: Colloid, HES, Hypertonic saline
  • Lokman Hekim University Affiliated: Yes


Aim: The aim of this study was to compare intraoperative effects of hypertonic saline (HS, 3 % NaCl) in hypervolemic hemodilution versus 6 % hydroxyethyl starch (HES, mean molecular weight 130kDA/0.4) on hemodynamic and coagulation parameters in patients scheduled for total hip replacement surgery. Materials and Methods: Twenty patients scheduled to undergo total hip replacement with standard spino-epidural anesthesia were randomly allocated into two groups. Study solutions consisting of either HS % 3 or HES 6 % solutions in coded bags were delivered at a dose of 250 mL/m2 in 20 minutes. Vital signs and, laboratory parameters such as complete blood count, prothrombin time, activated partial thromboplastin time and fibrinogen, coagulation factors (II, V, VII, VIII, X) were assessed before and after study fluid loading, after completion of the surgery and 24 hours after the surgery. Results: The mean (±SD) amount of the study fluids infused were 382±135 mL HS and 459±67 mL HES. Hemoglobin concentrations and platelet counts decreased with time, mean blood pressures and heart rates remained stable before and after fluid loading (p<0.05 within group comparison). There was no significant difference in transfusion requirements, estimates of hemodynamic parametres, complete blood counts or any one of the coagulation parameters among groups at predetermined times. Conclusion: In patients undergoing total hip prosthesis replacement, loading with 3 % hypertonic saline and 6 % HES result in similar coagulation and hemodynamic changes.