Evaluation of the correlation between plasma amylase and lipase levels and phthalate exposure in pubertal gynecomastia patients Fitalat temasi ile plazma amilaz ve lipaz düzeyleri arasindaki ilişkinin pubertal jinekomasti hastalarinda deǧerlendirilmesi

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ERKEKOĞLU Ü. P., Giray B., Durmaz E., Özmert E., Kizilgün M., DERMAN O., ...More

Turk Pediatri Arsivi, vol.45, no.4, pp.366-370, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.4274/tpa.45.366
  • Journal Name: Turk Pediatri Arsivi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.366-370
  • Keywords: alpha-amylase, Di (2-ethylhexyl) phthalate (DEHP), gynecomastia, lipase, mono (2-ethylhexyl) phthalate (MEHP), PANCREAS, ALPHA, RATS
  • Lokman Hekim University Affiliated: No


Aim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and α-amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas. Material and Method: The study group was composed of 40 pubertal gynecomastia patients. Plasma phthalate levels (Di(2-ethylhexyl) phthalate, DEHP and mono (2-ethylhexyl) phthalate, MEHP) were determined using HPLC. Plasma lipase and α-amylase levels were measured by using enzymatic colorimetric assay. Results: Plasma DEHP and MEHP levels in gynecomatia patients were higher than the control group significantly. Significant negative correlations existed between α-amylase and MEHP levels in gynecomastia (r=-0.388, p<0.05) and overall study groups (r=-0.353, p<0.05). Negative correlation between DEHP and α-amylase levels was found to be significant in overall study group (r=-0.323, p<0.05). Conclusions: The results suggest that phthalate exposure might cause significant decreases in α-amylase secretion. The inverse correlation observed might be explained by the PPARγ (peroxisome proliferator-activated receptor gamma)-activation of phthalates.