Quantitative Proton Magnetic Resonance Analysis of Primidone in Solid Dosage Forms

ÖZDEN M. S., Ozden T., Gilmus F., Tosun A.

Spectroscopy Letters, vol.22, no.4, pp.471-476, 1989 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 1989
  • Doi Number: 10.1080/00387018908053896
  • Journal Name: Spectroscopy Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.471-476
  • Keywords: PMR Analysis, Primidone
  • Lokman Hekim University Affiliated: No


A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining primidone in tablets. Maleic acid was used as the internal standart and DMSO-d6 served as the PMR solvent. Commercial DMSO was also used as the solvent and since the resonance signals of primidone and meleic acid used in the analysis did not interfere with the signal and side bands of DMSO good results were obtained. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of primidone at 7.53 6 ppm and maleic acid at 6.50 6 ppm. The average recovery value for primidone added to synthetic samples in concentrations ranging from 160 to 200 mg, was 99.9 2 0.2 Yo (SD) with a coefficient variation of 0.2 YO. The method using commercial products gave comparable to those obtained by the method of USP XXI. © 1989, Taylor & Francis Group, LLC. All rights reserved.