APOPTOZİS


Atıcı Y.

Mustafa Kemal Üniversitesi Tıp Dergisi, no.3, pp.26-37, 2015 (Peer-Reviewed Journal)

  • Publication Type: Article / Review
  • Publication Date: 2015
  • Journal Name: Mustafa Kemal Üniversitesi Tıp Dergisi
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.26-37
  • Lokman Hekim University Affiliated: No

Abstract

Apoptosis is main kind of programmed cell death. It is a way of getting rid of unnecessary and abnormal cells. Apoptozis is necessary and useful for life cyle and different from necrosis, which is cell death because of acute cell damage, by the way of killing cells in a series molecular pathways. For example during embriological differentiation of human fingers, apoptosis must be started to separate the fingers from each other. The differention of cell shape and metabolism at the time of apoptosis occurs as a result of several enzymatical procedures. Being smaller while dying by the apoptosis is not seen during necrosis. In every seconds one million cells are eliminated by apoptosis. Controlled balance is provided between mitosis and apoptosis. Apoptosis provides usefulness for organisms and also damages cancer cells. There are variety of methods which are detected to apoptosis. Apoptosis disorders can result in cancer, infections, neurodegenerative diseases, ischemic diseases and other possible related diseases. The parameter in the biochemical pathways of apoptosis can be targeted in the treatment of diseases which caused by apoptosis fewness or excess.