Akademik Veri Yönetim Sistemi
Gazi Medical Journal, cilt.13, sa.4, ss.187-190, 2002 (Scopus)
Purpose: The measurement of serum glycated hemoglobin levels (HbA1C) is a useful index in the management of diabetes mellitus. Many authors have shown a variety of reference values obtained using different forms of high performance liquid chromatography (HPLC); this reinforces the importance of determining reference values for each clinical laboratory. The aim of this study was to determine the reference values of HbA1C in adults and to assay the influence of sex and pregnancy on them. Methods: We investigated 60 (30 females and 30 males) healthy adults and 68 pregnant women admitted to Gazi University Medical School. HbA1C levels were measured by HPLC. Results: Reference limits for HbA1C were determined as 3.31-5.39% for the whole adult population, 3.23-5.63% for men, 3.42-5.14% for women and 1.96-4.40% for pregnant women (2.5 and 97.5 percentiles). The results showed that there was no difference between females and males (p>0.05). HbA1C levels were found to be significantly different between pregnant and nonpregnant women (p<0.01). Conclusion: Ethnic and socioeconomic differences between populations influence HbA1C reference values. In addition, HbA1C concentrations are lower in pregnancy.