Four new spectrophotometric methods for simultaneous determination of niclosamide and thiabendazole in tablets

ONUR F., DİNÇ E.

Scientia Pharmaceutica, cilt.64, sa.2, ss.151-172, 1996 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 2
  • Basım Tarihi: 1996
  • Dergi Adı: Scientia Pharmaceutica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-172
  • Anahtar Kelimeler: niclosamide, pharmaceutical preparations, simultaneous determination, spectrophotometry, thiabendazole
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Four new spectrophotometric methods, Vierordt's method, its modified version, absorbancy ratio method and selective precipitation of thiabendazole in mixture using picric acid then followed by determination of niclosamide by first derivative spectrophotometry have been used for the simultaneous determination of niclosamide and thiabendazole in their binary mixture. Mean recoveries, relative standard deviations, linearity ranges in calibration graphs of the methods were compared with each other. These four methods have been successfully applied to a commercial pharmaceutical preparation, tablet, containing thiabendazole and niclosamide.