Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers

Güven Ö. Ö., Erdoǧan T., GÖKER A. H., YILDIZ S.

Bioorganic and Medicinal Chemistry Letters, vol.17, no.8, pp.2233-2236, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1016/j.bmcl.2007.01.061
  • Journal Name: Bioorganic and Medicinal Chemistry Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2233-2236
  • Keywords: phenyl, 1H-benzimidazole, benzyl ether, antibacterial, antifungal, ANTIFUNGAL ACTIVITY, DERIVATIVES
  • Lokman Hekim University Affiliated: No

Abstract

In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 μg/mL against S. aureus and MRSA, respectively. © 2007 Elsevier Ltd. All rights reserved.