Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Pediatri, cilt.20, sa.4, ss.275-281, 2011 (Scopus)
Objective: Symptomatic hypoglycemia in the newborn period is associated with long-term neurodevelopmental impairments. The nature of the hypoglycemic insult and long term neurodevelopmental outcomes and their relationship to brain injury patterns identified on magnetic resonance imaging were poorly defined. Material and Methods: Thirty nine patients with symptomatic neonatal hypoglycemia were included in the study. For the assessment of psychomotor development, percentage of developmental age was determined by Denver Developmental Screening test and Wechsler intelligence scale for children. All patients underwent magnetic resonance imaging as part of the follow-up. Results Half of the patients had symptomatic partial epilepsy, six of them were medically intractable. Four children in the sample had language-cognitive delay, 5 children had fine motor development delay, none had gross motor development delay, and one of the children had social skills-self care development delay. There was no relationship between neurologic sequelaes and glucose levels. Ten patients suffered from visual impairment; four of them had optic atrophy, three had cortical blindness, three had alternating exotrophia. Sixteen patients demonstrated occipital lob injury, nine had parieto-occipital and five had parietal gliosis or volume loss. Imaging findings were normal in 5 patients. There was no relationship between magnetic resonance imaging findings and glucose levels. Conclusion: Neonatal hypoglycemia seems to play an important role in the development delay, especially on language-cognitive and fine motor development. Epilepsy, mental motor retardation, and visual impairments and are the most commonly reported outcomes associated with neonatal hypoglycemia Prompt recognition and treatment of neonatal hypoglycemia is essential to prevent and minimize future neurological sequelae. The patterns of injury associated with symptomatic neonatal hypoglycemia are more diverse and common than reported previously. Copyright © 2011 by Türkiye Klinikleri.