Akademik Veri Yönetim Sistemi
EURASIAN JOURNAL OF HEALTH SCIENCES, cilt.3, sa.5, ss.37-44, 2022 (Hakemli Dergi)
Objective: In individuals with COVID-19 infection, hematological and inflammatory parameters are crucial in terms of determining the
severity of the disease, to evaluate the risk factors and to designate the prognosis of the disease. These parameters may vary depending
on age and sex. In this study, we aimed to examine the changes in the Neutrophil/Lymphocyte ratio (NLR), C-Reactive Protein (CRP), Ferritin,
Lactate Dehydrogenase (LDH), D-Dimer and the Systemic immune inflammation index (SII) parameters in patients with COVID-19 infection
according to age and sex. Method: A total of 322 COVID-19 PCR positive patients (Female: 180, Male: 142) who were admitted to Lokman Hekim
University, Ankara Hospital between March 2019 and August 2021 were included in the study. The patients were divided into five age groups
(1st group: 1-17 years; 2nd group: 18-30 years; 3rd group: 31-45 years; 4th group: 46-60 years; 5th group: 61-92 years). Laboratory results
and demographic findings of PCR-positive patients were reviewed retrospectively. Leukocyte, NLR, CRP, Ferritin, LDH, D-Dimer, SII values
of the patients who participated in the study were examined. Results: When NLR, CRP, Ferritin, LDH, D-Dimer parameters were evaluated
according to age groups, a significant difference was found (p<0.05). When the 1st and 2nd groups were compared, there was a significant
difference in the D-Dimer level. When the first and 3rd groups were compared, there was a significant difference in LDH, Leukocyte and CRP
levels. When the 1st and 4th groups were compared, there was a significant difference in the CRP levels. When the 1st and 5th groups were
evaluated, a significant difference was observed in the levels of Ferritin, NLR, and CRP (p<0.05). When the correlations of NLR, CRP, Ferritin,
LDH and D-Dimer values with respect to age were examined, CRP, LDH and Ferritin levels showed a moderate correlation (r=0.557, r=0.408,
r=0.400, respectively); No correlation was observed in NLR, D-Dimer and Leukocyte values. When evaluated according to sex, infection-
related parameters (CRP, NLR, Leukocyte and Ferritin) were found to be higher in males (p<0.05). When SII values were evaluated according
to age and sex, no significant difference was observed (p>0.05). Conclusion: Since inflammatory and prognostic markers vary in patients
who are infected with COVID-19, we think that it would be useful to evaluate Leukocyte, NLR, CRP, Ferritin, LDH, D-Dimer parameters and the
demographic data in a holistic manner for the follow-up of the infection.