Antimalarial Activity Screening of Some Alkaloids and the Plant Extracts from Amaryllidaceae

Sener B., Orhan İ., Satayavivad J.

Phytotherapy Research, vol.17, no.10, pp.1220-1223, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2003
  • Doi Number: 10.1002/ptr.1346
  • Journal Name: Phytotherapy Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1220-1223
  • Keywords: antimalarial activity, Amaryllidaceae, Plasmodium falciparum, alkaloid
  • Lokman Hekim University Affiliated: No

Abstract

Four groups of Amaryllidaceae alkaloids, namely lycorine-, crinine-, tazettine-, and galanthamine-type, as well as plant extracts of the Amaryllidaceae plants (Pancratium maritimum, Leucojum aestivum, and Narcissus tazetta ssp. tazetta) growing in Turkey were evaluated in vitro for their ability to inhibit Plasmodium falciparum growth by a high-throughput screening method with a 96-well microtiter plate. All four groups of alkaloids exhibited antimalarial activity at different potencies. 6-Hydroxyhaemanthamine, haemanthamine and lycorine were found to be the most potent alkaloids against P. falciparum (T9.96) and galanthamine and tazettine had the least potent activity against P. falciparum (K1). Copyright © 2003 John Wiley & Sons, Ltd.