Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba

Hennebelle T., ŞAHPAZ S., Gressier B., Joseph H., Bailleul F.

Phytotherapy Research, cilt.22, sa.2, ss.256-258, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/ptr.2266
  • Dergi Adı: Phytotherapy Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.256-258
  • Anahtar Kelimeler: Lippia alba, antioxidant, sedative, iridoid, phenylpropanoid, flavonoid
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABAA receptors. The most active compound was luteolin-7- diglucuronide, with half maximal inhibitory concentrations (IC50) of 101 and 40 μM, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems. Copyright © 2007 John Wiley & Sons, Ltd.