Formulation and comparative bioavailability of conventional and sustained release furosemide tablets

Farshi F., ÇAPAN Y., Kes S., Hincal A.

S.T.P. Pharma Pratiques, cilt.5, sa.5, ss.361-366, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 5
  • Basım Tarihi: 1995
  • Dergi Adı: S.T.P. Pharma Pratiques
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.361-366
  • Anahtar Kelimeler: bioavailability, dissolution, formulation, furosemide, sustained release tablets
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The release of furosemide incorporated into hydroxypropylmethyl cellulose (HPMC) matrix tablets and conventional tablets was studied in vitro using different dissolution media. The data obtained from in vitro tests showed that the formulation containing 20% HPMC yields good sustained release matrix tablets. The pH 6.6. dissolution medium (compared to pH 4.6, 5.8 and 7.2) appears to be an appropriate test medium for assuring the difference among dosage forms for predicting in vivo bioavailability. The formulated sustained release tablet of 40 mg furosemide was investigated for its bioavailability properties in comparison with conventional tablets containing 40 mg furosemide (Lasikal) in six healthy subjects. Compared to the conventional tablets, the sustained release tablets exhibited lower peak furosemide concentrations, longer t(max) values, and reduced bioavailability (77%). No significant adverse effect was experienced with any of the preparations.