Formulation and comparative bioavailability of conventional and sustained release furosemide tablets

Farshi F., ÇAPAN Y., Kes S., Hincal A.

S.T.P. Pharma Pratiques, vol.5, no.5, pp.361-366, 1995 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 5
  • Publication Date: 1995
  • Journal Name: S.T.P. Pharma Pratiques
  • Journal Indexes: Scopus
  • Page Numbers: pp.361-366
  • Keywords: bioavailability, dissolution, formulation, furosemide, sustained release tablets
  • Lokman Hekim University Affiliated: No


The release of furosemide incorporated into hydroxypropylmethyl cellulose (HPMC) matrix tablets and conventional tablets was studied in vitro using different dissolution media. The data obtained from in vitro tests showed that the formulation containing 20% HPMC yields good sustained release matrix tablets. The pH 6.6. dissolution medium (compared to pH 4.6, 5.8 and 7.2) appears to be an appropriate test medium for assuring the difference among dosage forms for predicting in vivo bioavailability. The formulated sustained release tablet of 40 mg furosemide was investigated for its bioavailability properties in comparison with conventional tablets containing 40 mg furosemide (Lasikal) in six healthy subjects. Compared to the conventional tablets, the sustained release tablets exhibited lower peak furosemide concentrations, longer t(max) values, and reduced bioavailability (77%). No significant adverse effect was experienced with any of the preparations.