Use of sevoflurane during cardiopulmonary bypass decreases incidence of awareness

Celebioǧlu B., Pamuk A., AYPAR Ü., Paşaoǧlu I.

European Journal of Anaesthesiology, vol.19, no.4, pp.283-287, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1097/00003643-200204000-00006
  • Journal Name: European Journal of Anaesthesiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.283-287
  • Keywords: Anaesthetics, inhalation, sevoflurane, Mental processes, cognition, awareness, Psychological phenomena and processes, mental processes, perception, auditory perception, Surgical procedures, perative, extracorporeal circulation, cardiopulmonary bypass
  • Lokman Hekim University Affiliated: Yes


Background and objective: The role of sevoflurane has not been studied in relation to awareness during anaesthesia. We observed the effect of sevoflurane on the incidence of awareness during cardiopulmonary bypass for open-heart surgery. Methods: Fifty-nine patients of age > 17 yr undergoing open-heart surgery with cardiopulmonary bypass were randomly assigned to two groups. In both groups, induction was with etomidate, dehydrobenzperidol and fentanyl; anaesthesia was maintained with sevoflurane, fentanyl and N2O; vecuronium was used for muscular paralysis. Group 1 (30 patients) received dehydrobenzperidol and fentanyl during cardiopulmonary bypass; Group 2 (29 patients) received sevoflurane and fentanyl. Patients were given different auditory inputs during different phases of surgery. All patients were interviewed with standard questions 8 and 24 h postoperatively for evidence of explicit awareness. Results: Five patients in the dehydrobenzperidol group gave a history of awareness (16.67%) opposed to none in the sevoflurane group. The difference in the incidences of awareness was significant (P < 0.05), but no differences were found between the interviews conducted at 8 and 24 h. Sevoflurane and opioid combination reduced the incidence of awareness in open-heart surgery.