Tigecycline therapy in pediatric patients with multidrug resistant bacteremia Tratamiento con tigeciclina en pacientes pediátricos con bacteriemia multirresistente

Ozkaya-Parlakay A., Gulhan B., Kanik-Yuksek S., Guney D., Gonulal D., Demirtas G., ...More

Enfermedades Infecciosas y Microbiologia Clinica, vol.38, no.10, pp.471-473, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1016/j.eimc.2019.12.018
  • Journal Name: Enfermedades Infecciosas y Microbiologia Clinica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, DIALNET
  • Page Numbers: pp.471-473
  • Keywords: Bacteremia, Multidrug-resistant, Tigecycline, Children
  • Lokman Hekim University Affiliated: No

Abstract

© 2020 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología ClínicaIntroduction: Multidrug resistance among bacteria increases the need for new therapeutic options. Tigecycline is one candidate drug, due to property of a wider anti-bacterial spectrum to multi-drug resistant (MDR) pathogens. However, it has still not been approved for use in pediatric patients. Methods: In this study the effectiveness and safety of tigecycline in children was assessed retrospectively. Results: A total of 36 pediatric patients, received tigecycline therapy with a median of 13 days (2–32 days). Tigecycline was used as a combination therapy in all cases. Microbiological eradication was achieved in 27 patients (75%) and clinical response was observed in 30 patients (83%). There were six cases (17%) of relapse. Conclusion: Our findings suggest that tigecycline may be an option for children with severe infections due to multidrug resistant bacteria.