TREATMENT OF METASTATIC MALIGNANT-MELANOMA WITH 24 HOURS CONTINUOUS VENOUS INFUSION OF DACARBAZINE AND CISPLATIN

ICLI F., KARAOGUZ H., DINCOL D., GUNEL N., DEMİRKAZIK A.

JOURNAL OF SURGICAL ONCOLOGY, cilt.48, sa.3, ss.199-201, 1991 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 1991
  • Doi Numarası: 10.1002/jso.2930480312
  • Dergi Adı: JOURNAL OF SURGICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.199-201
  • Anahtar Kelimeler: DISSEMINATED MELANOMA, CHEMOTHERAPY, CONTINUOUS INFUSION, PHASE-II, CHEMOTHERAPY, COMBINATION, VINBLASTINE, VINDESINE, THERAPY
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Twenty consecutive patients with metastatic malignant melanoma were treated with a combination of 24 hours continuous infusion of dacarbazine (250 mg/m2) and cisplatin (20 mg/m2) for 5 days every 3 weeks. One patient (5%) achieved a complete response (CR) and 3 patients (15%) obtained a partial response (PR) with an overall response rate of 20%. Minimal response was observed in 5 other patients (25%). Complete response duration was 8 months. Median response duration of partial responders was 7 months. Median survival of all responders (CR + PR) was 8.5 months. Toxicity was mild to moderate.